Ann: Unmarketable Parcel Share Sale Facility, page-73

Hi @Prestonian & all,

I agree, we are definately overdue a re-rate.  The comparison with other biotechs...it’s not a level playing field, that’s for sure.

I look at the science & where companies are up to with trials & the likelihood of successful therapeutics & the potential value on market of their pipeline drugs & technology.

Sure there has been increased interest in biotechs this year, which is great.  So why hasn’t DXB gone BOOM yet?  

Pros:

1.  We are entering a 2b trial with groundbreaking results from 2a.  The results also  include responders who have diabetic nephropathy.  There is nothing on the market that comes close to DXB trial results for CKD, or in the pipelines of Pharmas.  

We have orphan drug designation for FSGS from FDA.  It will be seperate from DMX-200 trial for Diabetic nephropathy.  Rare diseases are on the radar (not that I think Big Pharma care, more FDA status).   I believe 2b FSGS trial is in the 3 month lead up stage, monitoring patient stability prior to commencement on DMX-200, hence my belief we will get news soon.  

2.  CKD (Chronic Kidney Disease) or CRF as a previous acronym (Chronic Renal Failure), has multi-factorial causes, it’s something that according to Kidney.org.au will affect 1 in 3 Australians, with an aging population, will probably increase (as will Alzeihmers & Dementia for the people on ACW, love their research too & be investing there soon).  CKD can affect both young & old, it’s a global health problem with billions of people affected.  There is no cure, apart from a donated kidney when CKD gets to the stage of renal failure & dialysis & on the transplant list.

3.  Dimerix is a stable company, with trustworthy management with excellent credentials & previous successful experience with Pharma deals.  Our medical trial advisory board the same.  

4.  We have funding to complete 2b trials & beyond.  Essentially, we are de-risked.

Cons:

1.  A lack of understanding about CKD as a global health issue.  We can remedy this as DXB have been trying to do on their Twitter account.  I am sick of the BS too.  Dr B is a wealth of information.  

2.  Kidneys are not just a ‘wee’ filter (ie proteinuria, an indication of significant kidney disease), they regulate blood pressure & electrolyte balances in the blood, which with poor kidney function, can cause life threatening cardiac arrhythmias, they  maintain haemoglobin levels, stimulating Erythropoietin to maintain RBCs...the list goes on...kidney function is really important.

3.  Negativity on this board.  There shouldn’t be.  We are a well advanced biotech.  I don’t think it will be an issue on this board in the long run.  As far as biotechs go, my skin is in a majority here, for the “pro” reasons, as well as the “cons” (understanding of what DXB holds).